ROS1 Antibody

ArtNr	ABC-AM8639b-ev
Hersteller	Abcepta
Menge	50 ul
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Cell Biology Cell Status Adenocarcinoma Western Blot Oxidative Stress Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	1843CT776.78.21
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Birchmeier C.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:4799-4803(1990). Mungall A.J.,et al.Nature 425:805-811(2003). Matsushime H.,et al.Mol. Cell. Biol. 6:3000-3004(1986). Birchmeier C.,et al.Mol. Cell. Biol. 6:3109-3116(1986). Watkins D.,et al.Cancer Genet. Cytogenet. 72:130-136(1994).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Proto-oncogene tyrosine-protein kinase ROS,2.7.10.1,Proto-oncogene c-Ros,Proto-oncogene c-Ros-1,Receptor tyrosine kinase c-ros oncogene 1,c-Ros receptor tyrosine kinase,ROS1,MCF3,ROS
Similar products	ROS1, MCF3, ROS, Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, 2.7.10.1
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Manufacturer - Category	Primary Antibodies; Cancer; Signal Transduction; Anti-Kinome Antibodies
Manufacturer - Targets	This ROS1 antibody is generated from a mouse immunized with a recombinant protein of human ROS1.
Bio Background	Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Clonality	Monoclonal
Gene Name	ROS1
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Calculated Molecular Weight	263915
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	IHC: 1:250 WB: 1:4000
Antigen Type	Recombinant Protein

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