MSH6 Antibody

Recombinant Protein

1. Hered Cancer Clin Pract. 2009 Dec 23; 7(1):17. 2. Cancer Epidemiol Biomarkers Prev. 2009 Sep; 18(9):2460-7.

2956

Purified Mouse Monoclonal Antibody

Black line: Control Antigen (100 ng);
Purple line: Antigen(10ng);
Blue line: Antigen (50 ng);
Red line: Antigen (100 ng);

1/10000

WB

Figure 2: Western blot analysis using MSH6 mouse mAb against HEK293 (1), HCT116 (2), A549 (3), A431 (4), MCF-7 (5) and HepG2 (6) cell lysate.

1/500 - 1/2000

IHC

Figure 4: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using MSH6 mouse mAb with DAB staining.

1/200 - 1/1000

IF

Figure 6: Flow cytometric analysis of MCF-7 cells using MSH6 mouse mAb (green) and negative control (red).

1/200 - 1/400

152786

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. 

Purified recombinant fragment of human MSH6 expressed in E. Coli.