SACA1 Antibody (N-term)

Synthetic Peptide

The correlation of anti-sperm antibodies with cases of
unexplained infertility implicates a role for these antibodies in
blocking fertilization. Improved diagnosis and treatment of
immunologic infertility, as well as identification of proteins for
targeted contraception, are dependent on the identification and
characterization of relevant sperm antigens. The protein expressed
by this gene is recognized by anti-sperm antibodies from infertile
males. Furthermore, antibodies generated against the recombinant
protein block in vitro fertilization. This protein localizes to the
acrosomal membrane of spermatids and mature spermatozoa where it is
thought to play a role in acrosomal morphogenesis and in sperm-egg
binding and fusion, respectively.

Polyclonal

81833

Affinity Purified Rabbit Polyclonal Antibody (Pab)

SACA1 Antibody (N-term) (Cat. #AP10775a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SACA1 antibody detected the SACA1 protein (arrow).

1:1000

IHC-P

SACA1 Antibody (N-term) (Cat. #AP10775a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

1:10~50

Rabbit Ig

46-74

This SACA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human SACA1.