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CASP5 Antibody (Center)

CASP5 Antibody (Center)

ArtNr	ABC-AP10944b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, FC, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Ulybina, Y.M., et al. Exp. Gerontol. 45(9):726-729(2010) Notaridou, M., et al. Int. J. Cancer (2010) In press: Kim, M.S., et al. APMIS 118(4):308-312(2010) Liang, X.S., et al. Br. J. Haematol. 146(4):418-423(2009) Eckhart, L., et al. Biochem. Biophys. Res. Commun. 348(2):682-688(2006)
NCBI	NP_001129581.1,NP_001129582.1,NP_001129584.1,NP_004338.3
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase-5,CASP-5,ICE(rel)-III,Protease ICH-3,Protease TY,Caspase-5 subunit p20,Caspase-5 subunit p10,CASP5,ICH3
Similar products	Caspase-5, CASP5, Caspase-5 subunit p20, ICH3, Protease ICH-3, CASP-5, ICE(rel)-III, Protease TY, Caspase-5 subunit p10
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Manufacturer - Category	Primary Antibodies; Cell Biology; Inflammasome
Manufacturer - Targets	This CASP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human CASP5.
Bio Background	This gene encodes a member of the cysteine-aspartic acidprotease (caspase) family. Sequential activation of caspases playsa central role in the execution-phase of cell apoptosis. Caspasesexist as inactive proenzymes which undergo proteolytic processingat conserved aspartic residues to produce two subunits, large andsmall, that dimerize to form the active enzyme. Overexpression ofthe active form of this enzyme induces apoptosis in fibroblasts.Max, a central component of the Myc/Max/Mad transcriptionregulation network important for cell growth, differentiation, andapoptosis, is cleaved by this protein; this process requiresFas-mediated dephosphorylation of Max. The expression of this geneis regulated by interferon-gamma and lipopolysaccharide.Alternatively spliced transcript variants have been identified forthis gene.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB18988
Gene Name	CASP5 {ECO:0000303\|PubMed:16893518, ECO:0000312\|HGNC:HGNC:1506}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	49736
Antigen Source	HUMAN
Antigen Region	162-191
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB: 1:2000 WB: 1:1000 IHC-P: 1:50~100 FC: 1:10~50
Antigen Type	Synthetic Peptide

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Menge: 400 ul

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