ATG12 Antibody (N-term)

Synthetic Peptide

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).

APG12L is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy.

Polyclonal

9140

Purified Rabbit Polyclonal Antibody (Pab)

Mouse leukaemic monocyte macrophage cells treated with vinblastine for 1 hr. APG12L antibody (Cat AP1151a) detected punctuate staining indicative of nascent autophagic vacuole structures. Data courtesy of Dr. Barry Boland, Department of Pharmacology, Oxford University.

1:50~100

15113

HUMAN

NP_001264712.1; NP_004698.3