AXIN1 Antibody (C-term)

Primary Antibodies; Cell Biology; Signal Transduction; Anti-Wnt-Pathway (plus Lgr5) Antibodies

This gene encodes a cytoplasmic protein which contains aregulation of G-protein signaling (RGS) domain and a dishevelledand axin (DIX) domain. The encoded protein interacts withadenomatosis polyposis coli, catenin beta-1, glycogen synthasekinase 3 beta, protein phosphate 2, and itself. This proteinfunctions as a negative regulator of the wingless-type MMTVintegration site family, member 1 (WNT) signaling pathway and caninduce apoptosis. The crystal structure of a portion of thisprotein, alone and in a complex with other proteins, has beenresolved. Mutations in this gene have been associated withhepatocellular carcinoma, hepatoblastomas, ovarian endometriodadenocarcinomas, and medullablastomas. Two transcript variantsencoding distinct isoforms have been identified for this gene.

RB31751

Affinity Purified Rabbit Polyclonal Antibody (Pab)

95635

710-738

WB: 1:1000
IHC-P: 1:10~50