FAS Antibody (C-term Y291)

Primary Antibodies; Cancer; Cell Biology; Immunology; Signal Transduction; Allograft rejection

The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor contains a death domain. Ithas been shown to play a central role in the physiologicalregulation of programmed cell death, and has been implicated in thepathogenesis of various malignancies and diseases of the immunesystem. The interaction of this receptor with its ligand allows theformation of a death-inducing signaling complex that includesFas-associated death domain protein (FADD), caspase 8, and caspase1. The autoproteolytic processing of the caspases in the complextriggers a downstream caspase cascade, and leads to apoptosis. Thisreceptor has been also shown to activate NF-kappaB, MAPK3/ERK1, andMAPK8/JNK, and is found to be involved in transducing theproliferating signals in normal diploid fibroblast and T cells. Atleast eight alternatively spliced transcript variants have beendescribed, some of which are candidates for nonsense-mediated decay(NMD). The isoforms lacking the transmembrane domain may negativelyregulate the apoptosis mediated by the full length isoform.

RB11173

Affinity Purified Rabbit Polyclonal Antibody (Pab)

37732

269-298

WB: 1:1000