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Bax Antibody (BH3 Domain Specific)

Bax Antibody (BH3 Domain Specific)

ArtNr	ABC-AP1302a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Cell Biology Cell Status Apoptosis Flow Cytometry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, FC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Liu, F.T., et al., Biochem. Biophys. Res. Commun. 310(3):956-962 (2003). Roucou, X., et al., J. Biol. Chem. 278(42):40877-40881 (2003). Cao, X., et al., Blood 102(7):2605-2614 (2003). McJilton, M.A., et al., Oncogene 22(39):7958-7968 (2003). Bidere, N., et al., J. Biol. Chem. 278(33):31401-31411 (2003).
NCBI	NP_004315.1,NP_620116.1,NP_620118.1,NP_620119.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Apoptosis regulator BAX,Bcl-2-like protein 4,Bcl2-L-4,BAX,BCL2L4
Similar products	BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4
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Manufacturer - Category	Crown Antibodies; Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Amyotrophic Lateral Sclerosis (ALS); Viral process; Host-virus interaction; Apoptosis; Apoptosis signaling; Mitochondrion
Manufacturer - Targets	This Bax antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-76 amino acids from human Bax.
Bio Background	Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB0952
Gene Name	BAX
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Predicted Reactivity	B
Calculated Molecular Weight	21184
Antigen Source	HUMAN
Antigen Region	41-76
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB: 1:2000 WB: 1:2000 WB: 1:2000 WB: 1:2000 FC: 1:25
Antigen Type	Synthetic Peptide

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