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Hrk BH3 Domain Antibody

Hrk BH3 Domain Antibody

ArtNr	ABC-AP1311a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	HRK, BID3, Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, Neuronal death protein DP5
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Primary Accession	O00198
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.
Bio References	Wakabayashi, T., et al., Neurosci. Lett. 318(2):77-80 (2002). Inohara, N., et al., EMBO J. 16(7):1686-1694 (1997).
Clonality	Polyclonal
Clone/Animal Names	RB04688
Gene ID	8739
Gene Name	HRK
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Hrk-BH3 (Cat. #AP1311a) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Hrk antibody detected the Hrk protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Hrk BH3 Domain Antibody (Cat. #AP1311a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Hrk BH3 Domain Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	NP_003797
Isotype	Rabbit Ig
Calculated MW	9884
Antigen Region	15-50
Antigen Source	HUMAN
Target/Specificity	This Hrk BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-50 amino acids from human Hrk BH3 Domain.
NCBI Accession	NP_003797.1

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Menge: 400 ul

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