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SEC63 Antibody (N-term)

SEC63 Antibody (N-term)

ArtNr	ABC-AP13128A-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SEC63, SEC63L, Translocation protein SEC63 homolog
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Primary Accession	Q9UGP8
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Bio References	Waanders, E., et al. Clin. Genet. 78(1):47-56(2010) van Keimpema, L., et al. Liver Int. (2010) In press : Waanders, E., et al. Histochem. Cell Biol. 129(3):301-310(2008) You, K.T., et al. PLoS Biol. 5 (5), E109 (2007) : Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Clonality	Polyclonal
Clone/Animal Names	RB32397
Gene ID	11231
Gene Name	SEC63 {ECO:0000303\|PubMed:28375157, ECO:0000312\|HGNC:HGNC:21082}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	SEC63 Antibody (N-term) (Cat. #AP13128a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SEC63 antibody detected the SEC63 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	SEC63 Antibody (N-term) (Cat. #AP13128a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEC63 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	Q8VHE0; NP_009145.1
Predicted	M
Isotype	Rabbit Ig
Calculated MW	87997
Antigen Region	139-168
Antigen Source	HUMAN
Target/Specificity	This SEC63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the N-terminal region of human SEC63.
NCBI Accession	NP_009145.1

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Menge: 80 ul

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