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BNIP3 Antibody (BH3 Domain Specific)

BNIP3 Antibody (BH3 Domain Specific)

ArtNr	ABC-AP1321a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Cell Biology Cell Status Immunohistochemistry Immunofluorescence Autophagy Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	IF, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	References for protein: 1.Kothari, S., et al., Oncogene 22(30):4734-4744 (2003). 2.Lee, S.M., et al., Life Sci. 71(19):2267-2277 (2002). 3.Ray, R., et al., J. Biol. Chem. 275(2):1439-1448 (2000). 4.Chen, G., et al., J. Biol. Chem. 274(1):7-10 (1999). 5.Yasuda, M., et al., J. Biol. Chem. 273(20):12415-12421 (1998). References for HepG2 cell line: 1. Knowles BB, et al. (1980). Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209: 497-499.[ PubMed: 6248960]. 2. Darlington GJ, et al. (1987). Growth and hepatospecific gene expression of human hepatoma cells in a defined medium. In Vitro Cell. Dev. Biol. 23: 349-354.[PubMed: 3034851]. 3. Ihrke, G; Neufeld, EB; Meads, T; Shanks, MR; Cassio, D; Laurent, M; Schroer, TA; Pagano, RE et al. (1993). "WIF-B cells: an in vitro model for studies of hepatocyte polarity". Journal of Cell Biology 123 (6): 1761–1775. [PubMed:7506266]. 4. Mersch-Sundermann, V.; Knasmüller, S.; Wu, X. J.; Darroudi, F.; Kassie, F. (2004). "Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents". Toxicology 198 (1–3): 329–340. [PubMed:15138059].
NCBI	NP_004043.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3,BNIP3,NIP3
Similar products	BNIP3, NIP3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Metabolism; Microbiology; Autophagy; Catalog Updated; Host-virus interaction; Mitochondrion; Mitochondrion outer membrane; SARS-Human interaction partners
Manufacturer - Targets	This BNIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-252 amino acids from human BNIP3.
Bio Background	NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB3385
Gene Name	BNIP3
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Calculated Molecular Weight	21541
Antigen Source	HUMAN
Antigen Region	215-252
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	IF: 1:500 IF: 1:50~100 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

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