WNT3 Antibody (Center)

Primary Antibodies; Neuroscience; Signal Transduction; Anti-Wnt-Pathway (plus Lgr5) Antibodies

The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98% amino acid identity to mouse Wnt3protein, and 84% to human WNT3A protein, another WNT gene product.The mouse studies show the requirement of Wnt3 in primary axisformation in the mouse. Studies of the gene expression suggest thatthis gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of theWNT-beta-catenin-TCF signaling pathway. This gene is clustered withWNT15, another family member, in the chromosome 17q21 region.

RB34217

Affinity Purified Rabbit Polyclonal Antibody (Pab)

C, M, X

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide