SNAP23 Antibody (C-term)

Synthetic Peptide

Specificity of vesicular transport is regulated, in part,
by the interaction of a vesicle-associated membrane protein termed
synaptobrevin/VAMP with a target compartment membrane protein
termed syntaxin. These proteins, together with SNAP25
(synaptosome-associated protein of 25 kDa), form a complex which
serves as a binding site for the general membrane fusion machinery.
Synaptobrevin/VAMP and syntaxin are believed to be involved in
vesicular transport in most, if not all cells, while SNAP25 is
present almost exclusively in the brain, suggesting that a
ubiquitously expressed homolog of SNAP25 exists to facilitate
transport vesicle/target membrane fusion in other tissues. The
protein encoded by this gene is structurally and functionally
similar to SNAP25 and binds tightly to multiple syntaxins and
synaptobrevins/VAMPs. It is an essential component of the high
affinity receptor for the general membrane fusion machinery and is
an important regulator of transport vesicle docking and fusion. Two
alternative transcript variants encoding different protein isoforms
have been described for this gene.

Polyclonal

8773

Affinity Purified Rabbit Polyclonal Antibody (Pab)

SNAP23 Antibody (C-term) (Cat. #AP14590b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SNAP23 antibody detected the SNAP23 protein (arrow).

1:1000

WB

SNAP23 Antibody (C-term) (AP14590b)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SNAP23 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

1:10~50

Rabbit Ig

170-199

This SNAP23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-199 amino acids from the C-terminal region of human SNAP23.