CXCL11 Antibody (C-term)

NP_005400.1

Chemokines are a group of small (approximately 8 to 14
kD), mostly basic, structurally related molecules that regulate
cell trafficking of various types of leukocytes through
interactions with a subset of 7-transmembrane, G protein-coupled
receptors. Chemokines also play fundamental roles in the
development, homeostasis, and function of the immune system, and
they have effects on cells of the central nervous system as well as
on endothelial cells involved in angiogenesis or angiostasis.
Chemokines are divided into 2 major subfamilies, CXC and CC. This
gene is a CXC member of the chemokine superfamily. Its encoded
protein induces a chemotactic response in activated T-cells and is
the dominant ligand for CXC receptor-3. The gene encoding this
protein contains 4 exons and at least three polyadenylation signals
which might reflect cell-specific regulation of expression.
IFN-gamma is a potent inducer of transcription of this gene.

6373

H

64-93

This CXCL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-93 amino acids from the C-terminal region of human CXCL11.