SSX4 Antibody (Center)

Primary Antibodies; Cancer; Metabolism

The product of this gene belongs to the family of highlyhomologous synovial sarcoma X (SSX) breakpoint proteins. Theseproteins may function as transcriptional repressors. They are alsocapable of eliciting spontaneously humoral and cellular immuneresponses in cancer patients, and are potentially useful targets incancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes havebeen involved in the t(X; 18) translocation characteristically foundin all synovial sarcomas. This translocation results in the fusionof the synovial sarcoma translocation gene on chromosome 18 to oneof the SSX genes on chromosome X. Chromosome Xp11 contains asegmental duplication resulting in two identical copies of synovialsarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tailorientation. This gene, SSX4B, represents the more centromericcopy. Two transcript variants encoding distinct isoforms have beenidentified for this gene.

RB35495

Affinity Purified Rabbit Polyclonal Antibody (Pab)

21858

69-97

WB: 1:1000