CD45 Antibody (C-term)

Primary Antibodies; Cancer; Immunology; Neuroscience; Signal Transduction; Fc gamma R-mediated phagocytosis; T cell activation; T cell receptor signaling; JAK-STAT signaling; SARS-Human interaction partners

CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. The CD45 gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

RB00430

Purified Rabbit Polyclonal Antibody (Pab)

147486

1245-1275

WB: 1:1000
IHC-P: 1:10~50
FC: 1:10~50