Metabotropic Glutamate Receptor 8 Antibody (C-term)

Synthetic Peptide

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors,
that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Polyclonal

2918

Purified Rabbit Polyclonal Antibody (Pab)

The GRPRC1H C-term Pab (Cat. #AP1641a) is used in Western blot to detect GRPRC1H in mouse brain tissue lysate.

1:1000

Rat

101741

HUMAN

NP_000836.2; NP_001120795.1