CYTH4 Antibody (C-term)

NP_037517.1

The protein encoded by this gene is a member of the PSCD
family. Members of this family have identical structural
organization that consists of an N-terminal coiled-coil motif, a
central Sec7 domain, and a C-terminal pleckstrin homology (PH)
domain. The coiled-coil motif is involved in homodimerization, the
Sec7 domain contains guanine-nucleotide exchange protein (GEP)
activity, and the PH domain interacts with phospholipids and is
responsible for association of PSCDs with membranes. Members of
this family appear to mediate the regulation of protein sorting and
membrane trafficking. The encoded protein exhibits GEP activity in
vitro with both ARF1 and ARF5 but is inactive with ARF6. The
structures of this gene and CYTH1 are very similar. [provided by
RefSeq].

27128

H

291-319

This CYTH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-319 amino acids from the C-terminal region of human CYTH4.