DNMT3L Antibody (C-term)

Synthetic Peptide

CpG methylation is an epigenetic modification that is
important for embryonic development, imprinting, and X-chromosome
inactivation. Studies in mice have demonstrated that DNA
methylation is required for mammalian development. This gene
encodes a nuclear protein with similarity to DNA
methyltransferases. This protein is not thought to function as a
DNA methyltransferase as it does not contain the amino acid
residues necessary for methyltransferase activity. However, this
protein does stimulate de novo methylation by DNA cytosine
methyltransferase 3 alpha and it is thought to be required for the
establishment of maternal genomic imprints. This protein also
mediates transcriptional repression through interaction with
histone deacetylase 1. Alternative splicing results in two
transcript variants. An additional splice variant has been
described but its biological validity has not been determined.

Polyclonal

29947

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Anti-DNMT3L Antibody (C-term) at 1:1000 dilution + Jurkat whole cell lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 44 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:1000

Rabbit Ig

355-381

This DNMT3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-381 amino acids from the C-terminal region of human DNMT3L.