APG5 Antibody

ArtNr	ABC-AP1812C
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot Immunofluorescence Autophagy Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	References for protein: 1.Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) 2. Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) 3.Greenberg JT. Dev Cell. 8(6):799-801. (2005) 4.Levine B. Cell. 120(2):159-62. (2005) 5.Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004) 6. Hammond E.M., et al. FEBS Lett. 425:391-395(1998) 7.Strausberg R.L., et al. PNAS 99:16899-16903(2002) 8.Grand R.J.A., et al. Exp. Cell Res. 218:439-451(1995) 9. Mizushima N., et al. J. Biol. Chem. 273:33889-33892(1998) 10. Mizushima N., et al. J. Cell Biol. 152:657-668(2001) References for U251 cell line: 1. Westermark B.; Pontén J.; Hugosson R. (1973).” Determinants for the establishment of permanent tissue culture lines from human gliomas”. Acta Pathol Microbiol Scand A. 81:791-805. [PMID: 4359449]. 2. Pontén, J.,Westermark B. (1978).” Properties of Human Malignant Glioma Cells in Vitro”. Medical Biology 56: 184-193.[PMID: 359950]. 3. Geng Y.;Kohli L.; Klocke B.J.; Roth K.A.(2010). “Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent”. Neuro Oncol. 12(5): 473–481.[ PMID: 20406898].
NCBI	NP_004840.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Autophagy protein 5,APG5-like,Apoptosis-specific protein,ATG5,APG5L,ASP
Similar products	ATG5, ASP, APG5L, Autophagy protein 5, APG5-like, Apoptosis-specific protein
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Metabolism; Autophagy; Immunity; Innate immunity; RIG-l-like Receptor; Autophagy; Regulation of autophagy
Manufacturer - Targets	This ATG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the full length of human ATG5.
Bio Background	Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG5, required for autophagy, conjugates to ATG12 and associates with an isolation membrane to form a cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may also play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB12327
Gene Name	ATG5
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	32447
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by dialysis against PBS.
Dilution	IF: 1:200 WB: 1:1000 WB: 1:500 WB: 1:500 IHC-P: 1:10~50
Antigen Type	Recombinant Protein

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Menge: 400 ul

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