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ATG12 Antibody (N-term)

ATG12 Antibody (N-term)

ArtNr	ABC-AP1816a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot Immunofluorescence Autophagy Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	References for protein: 1.Yee, K.S. et al. Cell Death Differ. August; 16(8): 1135?145.(2009) 2.Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) 3.Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) 4.Greenberg JT. Dev Cell. 8(6):799-801. (2005) 5.Levine B. Cell. 120(2):159-62. (2005) 6.Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004) References for U251 cell line: 1. Westermark B.; Pontén J.; Hugosson R. (1973).” Determinants for the establishment of permanent tissue culture lines from human gliomas”. Acta Pathol Microbiol Scand A. 81:791-805. [PMID: 4359449]. 2. Pontén, J.,Westermark B. (1978).” Properties of Human Malignant Glioma Cells in Vitro”. Medical Biology 56: 184-193.[PMID: 359950]. 3. Geng Y.;Kohli L.; Klocke B.J.; Roth K.A.(2010). “Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent”. Neuro Oncol. 12(5): 473–481.[ PMID: 20406898].
NCBI	NP_001264712.1,NP_004698.3
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ubiquitin-like protein ATG12,Autophagy-related protein 12,APG12-like,ATG12,APG12,APG12L
Similar products	ATG12, APG12, APG12L, Ubiquitin-like protein ATG12, Autophagy-related protein 12, APG12-like
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Metabolism; Autophagy; Immunity; Innate immunity; RIG-l-like Receptor; Autophagy; Regulation of autophagy
Manufacturer - Targets	This ATG12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ATG12.
Bio Background	Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG12L is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB7475
Gene Name	ATG12
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	15113
Antigen Source	HUMAN
Antigen Region	1-30
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IF: 1:200 WB: 1:2000 IHC-P: 1:50~100 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

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Menge: 400 ul

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