Beclin 1 Antibody

ArtNr	ABC-AP1818b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, FC, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005) Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005) Greenberg JT. Dev Cell. 8(6):799-801. (2005) Levine B. Cell. 120(2):159-62. (2005) Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004) Liang,X.H., et al. J. Virol. 72 (11), 8586-8596 (1998) Aita V.M., et al. Genomics 59:59-65(1999).
NCBI	NP_003757.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Beclin-1,Coiled-coil myosin-like BCL2-interacting protein,Protein GT197,BECN1,GT197
Similar products	Beclin-1, BECN1, GT197, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Metabolism; Microbiology; Autophagy; Antiviral defense; Host-virus interaction; Autophagy; Mitochondrion; Regulation of autophagy
Manufacturer - Targets	This Beclin 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from human Beclin 1.
Bio Background	Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB7463
Gene Name	BECN1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Predicted Reactivity	B, Pig, Rat
Calculated Molecular Weight	51896
Antigen Source	HUMAN
Antigen Region	210-239
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	WB: 1:1000 WB: 1:1000 WB: 1:4000 IHC-P: 1:50~100 FC: 1:10~50
Antigen Type	Synthetic Peptide

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