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DRAM Antibody (N-term)

DRAM Antibody (N-term)

ArtNr	ABC-AP1825a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	DRAM, DRAM1, Damage-regulated autophagy modulator, DNA damage-regulated autophagy modulator protein 1
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Primary Accession	Q8N682
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
Bio References	Kerley-Hamilton, J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007) Crighton, D., Autophagy 3 (1), 72-74 (2007) Crighton, D., Cell 126 (1), 121-134 (2006) Green, D.R., Cell 126 (1), 30-32 (2006)
Clonality	Polyclonal
Clone/Animal Names	RB12475
Gene ID	55332
Gene Name	DRAM1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of anti-DRAM Antibody (N-term) (Cat.#AP1825a) in HepG2 cell line lysates (35ug/lane). DRAM (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with *DRAM antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	Q9DC58
Predicted	M
Isotype	Rabbit Ig
Calculated MW	26253
Antigen Region	27-56
Antigen Source	HUMAN
Target/Specificity	This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human DRAM.
NCBI Accession	NP_060840.2

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