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LMNA Antibody (Center)

LMNA Antibody (Center)

ArtNr	ABC-AP18319c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Carcinoma Sarcoma Cell Biology Cytoskeleton Western Blot Primary Antibodies Intermediate filaments By Organ Breast Cancer
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Wegner, L., et al. J. Clin. Endocrinol. Metab. 95(8):3884-3892(2010) Drac, H., et al. Neurol. Neurochir. Pol. 44(3):291-296(2010) Liu, Q., et al. PLoS ONE 5 (5), E10874 (2010): Chaturvedi, P., et al. PLoS ONE 5 (5), E10620 (2010) :
NCBI	NP_001244303.1,NP_005563.1,NP_733821.1,NP_733822.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Prelamin-A/C,Lamin-A/C,70 kDa lamin,Renal carcinoma antigen NY-REN-32,LMNA,LMN1
Similar products	LMNA, LMN1, Prelamin-A/C, Lamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32
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Manufacturer - Category	Primary Antibodies; Cell Biology; Developmental Biology; Signal Transduction
Manufacturer - Targets	This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.
Bio Background	The nuclear lamina consists of a two-dimensional matrix ofproteins located next to the inner nuclear membrane. The laminfamily of proteins make up the matrix and are highly conserved inevolution. During mitosis, the lamina matrix is reversiblydisassembled as the lamin proteins are phosphorylated. Laminproteins are thought to be involved in nuclear stability, chromatinstructure and gene expression. Vertebrate lamins consist of twotypes, A and B. Through alternate splicing, this gene encodes threetype A lamin isoforms. Mutations in this gene lead to severaldiseases: Emery-Dreifuss muscular dystrophy, familial partiallipodystrophy, limb girdle muscular dystrophy, dilatedcardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilfordprogeria syndrome.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB21443
Gene Name	LMNA
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	74139
Antigen Source	HUMAN
Antigen Region	401-427
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB: 1:1000
Antigen Type	Synthetic Peptide

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 400 ul

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