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FADD Antibody(Center)

FADD Antibody(Center)

ArtNr	ABC-AP19607c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Antibodies By Cell Type Carcinoma Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010) Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010) Papoff, G., et al. Biochim. Biophys. Acta 1803(8):898-911(2010) Li, P., et al. J. Biol. Chem. 285(29):22713-22722(2010) Ko, C.L., et al. Chang Gung Med J 33(2):145-151(2010)
NCBI	NP_003815.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FAS-associated death domain protein,FAS-associating death domain-containing protein,Growth-inhibiting gene 3 protein,Mediator of receptor induced toxicity,Protein FADD,FADD,MORT1
Similar products	FADD, MORT1, Protein FADD, Mediator of receptor induced toxicity, FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein
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Manufacturer - Category	Primary Antibodies; Cancer; Cell Biology; Host-virus interaction; Immunity; Innate immunity; RIG-l-like Receptor; Toll-Like receptor signaling; Apoptosis; Apoptosis signaling
Manufacturer - Targets	This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.
Bio Background	The protein encoded by this gene is an adaptor moleculethat interacts with various cell surface receptors and mediatescell apoptotic signals. Through its C-terminal death domain, thisprotein can be recruited by TNFRSF6/Fas-receptor, tumor necrosisfactor receptor, TNFRSF25, and TNFSF1/TRAIL-receptor, and thus itparticipates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks theN-terminal effector domain of this protein, which allows it torecruit caspase-8, and thereby activate the cysteine proteasecascade. Knockout studies in mice also suggest the importance ofthis protein in early T cell development.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB40884
Gene Name	FADD {ECO:0000303\|PubMed:7538907, ECO:0000312\|HGNC:HGNC:3573}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	23279
Antigen Source	HUMAN
Antigen Region	106-135
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB: 1:1000
Antigen Type	Synthetic Peptide

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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