RELA Antibody (C-term S536)

Synthetic Peptide

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL
(MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex.
The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of
NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA,
MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by
trapping it in the cytoplasm. Phosphorylation of serine residues on
the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM
603258) marks them for destruction via the ubiquitination pathway,
thereby allowing activation of the NFKB complex. Activated NFKB
complex translocates into the nucleus and binds DNA at
kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or
5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G
purine; and Y is a C or T pyrimidine).

Polyclonal

5970

Affinity Purified Rabbit Polyclonal Antibody (Pab)

RELA Antibody (pS536) (Cat. #AP20211b) western blot analysis in SK-BR-3, mouse Neuro-2a cell line and mouse testis tissue lysates (35ug/lane).This demonstrates the RELA antibody detected the RELA protein (arrow).

1:1000

Rabbit Ig

516-542

This RELA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-542 amino acids from the C-terminal region of human RELA.