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SQSTM1 (p62) Antibody (C-term)

SQSTM1 (p62) Antibody (C-term)

ArtNr	ABC-AP2183B-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Oncology Neuroscience Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Cell Biology Cell Status Adenocarcinoma Immunohistochemistry Western Blot Immunofluorescence Autophagy Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	References for protein: 1.Seibenhener, M.L., et al., Mol. Cell. Biol. 24(18):8055-8068 (2004). 2.Eekhoff, E.W., et al., Arthritis Rheum. 50(5):1650-1654 (2004). 3.Brajenovic, M., et al., J. Biol. Chem. 279(13):12804-12811 (2004). 4.Kuusisto, E., et al., J. Neuropathol. Exp. Neurol. 62(12):1241-1253 (2003). 5. Johnson-Pais, T.L., et al., J. Bone Miner. Res. 18(10):1748-1753 (2003). References for U251 cell line: 1. Westermark B.; Pontén J.; Hugosson R. (1973).” Determinants for the establishment of permanent tissue culture lines from human gliomas”. Acta Pathol Microbiol Scand A. 81:791-805. [PMID: 4359449]. 2. Pontén, J.,Westermark B. (1978).” Properties of Human Malignant Glioma Cells in Vitro”. Medical Biology 56: 184-193.[PMID: 359950]. 3. Geng Y.;Kohli L.; Klocke B.J.; Roth K.A.(2010). “Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent”. Neuro Oncol. 12(5): 473–481.[ PMID: 20406898].
NCBI	NP_001135770.1,NP_001135771.1,NP_003891.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Sequestosome-1,EBI3-associated protein of 60 kDa,EBIAP,p60,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,Ubiquitin-binding protein p62,SQSTM1,ORCA,OSIL
Similar products	SQSTM1, p60, ORCA, OSIL, Sequestosome-1, EBI3-associated protein of 60 kDa, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBIAP
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cardiovascular; Metabolism; Signal Transduction; Autophagy; Immunity; Autophagy; Lysosome; SARS-Human interaction partners
Manufacturer - Targets	This SQSTM1 (p62) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-346 amino acids of human SQSTM1 (p62).
Bio Background	SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB4614
Gene Name	SQSTM1 {ECO:0000303\|PubMed:16286508, ECO:0000312\|HGNC:HGNC:11280}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Predicted Reactivity	Rat
Calculated Molecular Weight	47687
Antigen Source	HUMAN
Antigen Region	317-346
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IF: 1:200 IF: 1:50~100 WB: 1:2000 WB: 1:2000 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

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