STAT3(S727) Antibody

ArtNr	ABC-AP22381a-ev
Hersteller	Abcepta
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Akira S.,et al.Cell 77:63-71(1994). Della Pietra L.,et al.Gene 213:119-124(1998). Feinstein E.,et al.Patent number EP2440214, 18-APR-2012. Ota T.,et al.Nat. Genet. 36:40-45(2004). Zody M.C.,et al.Nature 440:1045-1049(2006).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Signal transducer and activator of transcription 3,Acute-phase response factor,STAT3,APRF
Similar products	STAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor
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Manufacturer - Category	Primary Antibodies; Cancer; Cardiovascular; Developmental Biology; Microbiology; Signal Transduction; Stem Cells; Viral process; Host-virus interaction; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Interleukin signaling; JAK-STAT signaling; Jak-STAT signaling KEGG
Manufacturer - Targets	This STAT3(S727) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 710-740 amino acids from the human region of human STAT3(S727).
Bio Background	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB60380
Gene Name	STAT3 {ECO:0000303\|PubMed:9630560, ECO:0000312\|HGNC:HGNC:11364}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Predicted Reactivity	H
Calculated Molecular Weight	88068
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IF: 1:25 WB: 1:2000 WB: 1:500
Antigen Type	Synthesized Peptide

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