MeCP2 Antibody

ArtNr	ABC-AP2545d
Hersteller	Abcepta
Menge	400 ul
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Epigenetics Antibodies Immunohistochemistry Western Blot Primary Antibodies Glial Cell Markers
Typ	Antibody Polyclonal
Applikationen	WB, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	dos Santos, J.M., et al., Neurosci. Lett. 379(1):13-16 (2005). Ylisaukko-Oja, T., et al., Am J Med Genet A 132(2):121-124 (2005). Schanen, C., et al., Am J Med Genet A 126(2):129-140 (2004). Shibayama, A., et al., Am. J. Med. Genet. B Neuropsychiatr. Genet. 128(1):50-53 (2004). Fang, J.Y., et al., World J. Gastroenterol. 10(23):3394-3398 (2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Methyl-CpG-binding protein 2,MeCp-2 protein,MeCp2,MECP2
Similar products	MECP2, Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2
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Manufacturer - Applications	IHC-P-Leica, WB
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	This MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-428 amino acids from human MeCP2.
Bio Background	DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB25959
Gene Name	MECP2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Calculated Molecular Weight	52441
Antigen Source	MACFA
Antigen Region	400-428
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB: 1:2000 WB: 1:2000 IHC-P: 1:500 IHC-P: 1:200
Antigen Type	Synthetic Peptide

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Menge: 400 ul

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