Phospho-DAXX(S213) Antibody

Primary Antibodies; Antibody Collections; Cell Biology; Microbiology; Amyotrophic Lateral Sclerosis (ALS); Phospho Antibodies; Viral process; Host-virus interaction; Apoptosis signaling

DAXX is proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. DAXX seems to regulate transcription in PML/POD/ND1 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. This protein down-regulates basal and activated transcription, and it also seems to act as a transcriptional co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. DAXX modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND1 nuclear bodies through interactions with MCSR1 and PML, respectively.

RB6929

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M, Rat

HUMAN

WB: 1:1000
IHC-P: 1:50~100