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Phospho-HER2(Y1112) Antibody

Phospho-HER2(Y1112) Antibody

ArtNr	ABC-AP3120a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, Dot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ERBB2, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, Tyrosine kinase-type cell surface receptor HER2, MLN 19, HER2, NEU, NGL, MLN19, Metastatic lymph node gene 19 protein, CD340
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Primary Accession	P04626
Antigen Type	Synthetic Peptide
Application	WB, DB
Bio Background	ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
Bio References	Provinciali, M., et al., Int. J. Cancer 115(1):36-45 (2005). Yee, L.D., et al., J. Nutr. 135(5):983-988 (2005). Beckers, J., et al., Int. J. Cancer 114(4):590-597 (2005). Brandt, B., et al., Biochem. Biophys. Res. Commun. 329(1):318-323 (2005). Ghatak, S., et al., J. Biol. Chem. 280(10):8875-8883 (2005).
Clonality	Polyclonal
Clone/Animal Names	RB41955
Gene ID	2064
Gene Name	ERBB2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of extracts from A431 cells, untreated or treated with EGF, 100ng/ml，using phospho HER2-Y1112 (left) or HER2 antibody(right)
Type image 1	WB
Dilution image 1	1:2000
Legend image 2	Dot blot analysis of Phospho-HER2-pY1112 Phospho-specific Pab (Cat. #AP3120a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
Type image 2	DB
Dilution image 2	1:500
Isotype	Rabbit Ig
Calculated MW	137910
Antigen Source	HUMAN
Target/Specificity	This HER2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1112 of human HER2.
NCBI Accession	NP_001005862.1; NP_004439.2

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ABC-AP3120a-datasheet.pdf

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Menge: 400 ul

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Lieferung vsl. bis 04.09.2025

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