Phospho-Rb(S788) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Phospho Antibodies; Viral process; Host-virus interaction

RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV4 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.

RB7670

Affinity Purified Rabbit Polyclonal Antibody (Pab)

106159

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide