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Phospho-INSR(Y1185) Antibody

Phospho-INSR(Y1185) Antibody

ArtNr	ABC-AP3554a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Primary Antibodies Dot Blot
Typ	Antibody Polyclonal
Applikationen	Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Nakamaru, K., et al., Biochem. Biophys. Res. Commun. 328(2):449-454 (2005). Diaz, E., et al., Clin. Biochem. 38(3):243-247 (2005). McGettrick, A.J., et al., J. Biol. Chem. 280(8):6441-6446 (2005). Schmitt, T.L., et al., J. Biol. Chem. 280(5):3795-3801 (2005). Denley, A., et al., Mol. Endocrinol. 18(10):2502-2512 (2004).
NCBI	NP_000199.2,NP_001073285.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Insulin receptor,IR,CD220,Insulin receptor subunit alpha,Insulin receptor subunit beta,INSR
Similar products	INSR, Insulin receptor, Insulin receptor subunit alpha, Insulin receptor subunit beta, IR, CD220
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction; Phospho Antibodies; Anti-Kinome Antibodies
Manufacturer - Targets	This INSR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR.
Bio Background	Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB15377
Gene Name	INSR
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	B, M, Rat, X, Dr
Calculated Molecular Weight	156333
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	DB: 1:500
Antigen Type	Synthetic Peptide

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 400 ul

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