Phospho-TERT(Y707) Antibody

Synthetic Peptide

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

Polyclonal

7015

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Confocal immunofluorescent analysis of Phospho-TERT-pY707 Antibody(Cat#AP3619a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).

1:10~50

DB

Rabbit Ig

HUMAN

NP_001180305.1; NP_937983.2