Phospho-NFKBIA(Ser32)) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Immunology; Signal Transduction; Phospho Antibodies; Viral process; Host-virus interaction; RIG-l-like Receptor; Toll receptor signaling; Toll-Like Receptor; Toll-Like receptor signaling; B cell receptor signaling; T cell activation; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Apoptosis; Apoptosis signaling

NFKB1 (MIM 16411) or NFKB2 (MIM 16412) is bound to REL (MIM 16491), RELA (MIM 16414), or RELB (MIM 64758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 64495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 6664, or IKBKB, MIM 63258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.

RB25830

Affinity Purified Rabbit Polyclonal Antibody (Pab)

35609

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide