Phospho-NF kappa B(S536) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Immunology; Metabolism; Microbiology; Neuroscience; Signal Transduction; Phospho Antibodies; Host-virus interaction; Inflammasome; RIG-l-like Receptor; Toll receptor signaling; Toll-Like Receptor; Toll-Like receptor signaling; B cell receptor signaling; Immune system process; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Apoptosis; Apoptosis signaling

NFKB1 (MIM 16411) or NFKB2 (MIM 16412) is bound to REL(MIM 16491), RELA, or RELB (MIM 64758) to form the NFKB complex.The p5 (NFKB1)/p65 (RELA) heterodimer is the most abundant form ofNFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 1648 or NFKBIB, MIM 64495), which inactivate NFKB bytrapping it in the cytoplasm. Phosphorylation of serine residues onthe I-kappa-B proteins by kinases (IKBKA, MIM 6664, or IKBKB, MIM63258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKBcomplex translocates into the nucleus and binds DNA atkappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).

RB22552

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M

HUMAN

DB: 1:500