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phospho-Sox2(S246) Antibody

phospho-Sox2(S246) Antibody

ArtNr	ABC-AP3750a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Carcinoma Immunofluorescence Primary Antibodies Dot Blot Calcium Binding Protein Markers Interneuron Markers
Typ	Antibody Polyclonal
Applikationen	IF, Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	References for protein: 1.Gen, Y., et al. Cancer Genet. Cytogenet. 202(2):82-93(2010) 2.Ji, J., et al. Hum. Pathol. 41(10):1438-1447(2010) 3.Fang, X., et al. OMICS 14(4):369-384(2010) 4.Sholl, L.M., et al. Am. J. Surg. Pathol. 34(8):1193-1198(2010) 5.Zhang, D., et al. BMC Med. Genet. 11, 116 (2010) References for SY5Y (SH-SY5Y; ATCC#CRL-2266): 1. Ross RA, et al. Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J. Natl. Cancer Inst. 71: 741-749, 1983. [PubMed: 6137586]; 2. Biedler JL, et al. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38: 3751-3757, 1978. [PubMed: 29704].
NCBI	NP_003097.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Transcription factor SOX-2,SOX2
Similar products	SOX2, Transcription factor SOX-2
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Developmental Biology; Neuroscience; Signal Transduction; Phospho Antibodies
Manufacturer - Targets	This Sox2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S246 of human Sox2.
Bio Background	This intronless gene encodes a member of the SRY-relatedHMG-box (SOX) family of transcription factors involved in theregulation of embryonic development and in the determination ofcell fate. The product of this gene is required for stem-cellmaintenance in the central nervous system, and also regulates geneexpression in the stomach. Mutations in this gene have beenassociated with optic nerve hypoplasia and with syndromicmicrophthalmia, a severe form of structural eye malformation. Thisgene lies within an intron of another gene called SOX2 overlappingtranscript (SOX2OT).
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB26203
Gene Name	SOX2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	M, Sh
Calculated Molecular Weight	34310
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IF: 1:200 DB: 1:500
Antigen Type	Synthetic Peptide

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