Phospho-AKT1(T450) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Immunology; Metabolism; Neuroscience; Signal Transduction; Phospho Antibodies; Toll-Like receptor signaling; B cell receptor signaling; Fc gamma R-mediated phagocytosis; T cell activation; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Interleukin signaling; Jak-STAT signaling KEGG; Apoptosis; Apoptosis signaling

The serine-threonine protein kinase encoded by the AKT1gene is catalytically inactive in serum-starved primary andimmortalized fibroblasts. AKT1 and the related AKT2 are activatedby platelet-derived growth factor. The activation is rapid andspecific, and it is abrogated by mutations in the pleckstrinhomology domain of AKT1. It was shown that the activation occursthrough phosphatidylinositol 3-kinase. In the developing nervoussystem AKT is a critical mediator of growth factor-induced neuronalsurvival. Survival factors can suppress apoptosis in atranscription-independent manner by activating the serine/threoninekinase AKT1, which then phosphorylates and inactivates componentsof the apoptotic machinery. Multiple alternatively splicedtranscript variants have been found for this gene. [provided byRefSeq].

RB29255

Affinity Purified Rabbit Polyclonal Antibody (Pab)

B, M, Rat

HUMAN

DB: 1:500