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Phospho-PTEN(T382) Antibody

Phospho-PTEN(T382) Antibody

ArtNr	ABC-AP3788e
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Metabolism Diabetes Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Primary Antibodies Dot Blot
Typ	Antibody Polyclonal
Applikationen	Dot
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Miletic, A.V., et al. J. Exp. Med. 207(11):2407-2420(2010) Kini, V., et al. J. Biol. Chem. 285(43):33082-33091(2010) Shimada, M., et al. Hum. Genet. 128(4):433-441(2010) Molina, J.R., et al. Cancer Res. 70(17):6697-6703(2010) Iliopoulos, D., et al. Mol. Cell 39(4):493-506(2010)
NCBI	NP_000305.3
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Phosphatidylinositol 3,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN,Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog,PTEN,MMAC1,TEP1
Similar products	PTEN, Phosphatidylinositol 3, TEP1, MMAC1, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Signal Transduction; Phospho Antibodies; Inflammation mediated by chemokine and cytokine signaling
Manufacturer - Targets	This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T382 of human PTEN.
Bio Background	This gene was identified as a tumor suppressor that ismutated in a large number of cancers at high frequency. The proteinencoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate3-phosphatase. It contains a tensin like domain as well as acatalytic domain similar to that of the dual specificity proteintyrosine phosphatases. Unlike most of the protein tyrosinephosphatases, this protein preferentially dephosphorylatesphosphoinositide substrates. It negatively regulates intracellularlevels of phosphatidylinositol-3, 4, 5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKBsignaling pathway.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB39727
Gene Name	PTEN
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	M, Rat, X
Calculated Molecular Weight	47166
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	DB: 1:500
Antigen Type	Synthetic Peptide

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 400 ul

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