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AXIN2 Antibody (C-term)

AXIN2 Antibody (C-term)

ArtNr	ABC-AP5416b-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, FC, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Inkster, B., et al. Neuroimage (2010) In press: Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010) Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010) Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009) Olschwang, S., et al. J Oncol 2009, 306786 (2009): Dong, X., et al. Cytogenet. Cell Genet. 93 (1-2), 26-28 (2001): Liu, W., et al. Nat. Genet. 26(2):146-147(2000) von Kries, J.P., et al. Nat. Struct. Biol. 7(9):800-807(2000) Kikuchi, A. Cytokine Growth Factor Rev. 10 (3-4), 255-265 (1999): Mai, M., et al. Genomics 55(3):341-344(1999)
NCBI	NP_004646.3
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Axin-2,Axin-like protein,Axil,Axis inhibition protein 2,Conductin,AXIN2
Similar products	AXIN2, Axil, Axin-2, Axin-like protein, Axis inhibition protein 2, Conductin
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Manufacturer - Category	Primary Antibodies; Cancer; Cell Biology; Neuroscience; Signal Transduction; Anti-Wnt-Pathway (plus Lgr5) Antibodies
Manufacturer - Targets	This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2.
Bio Background	The Axin-related protein, Axin2, presumably plays animportant role in the regulation of the stability of beta-cateninin the Wnt signaling pathway, like its rodent homologs, mouseconductin/rat axil. In mouse, conductin organizes a multiproteincomplex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to thedegradation of beta-catenin. Apparently, the deregulation ofbeta-catenin is an important event in the genesis of a number ofmalignancies. The AXIN2 gene has been mapped to 17q23-q24, a regionthat shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have beenassociated with colorectal cancer with defective mismatch repair.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB26798
Gene Name	AXIN2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	M, Rat
Calculated Molecular Weight	93568
Antigen Source	HUMAN
Antigen Region	816-843
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB: 1:1000 IHC-P: 1:50~100 FC: 1:10~50
Antigen Type	Synthetic Peptide

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