KIR2DS2 Antibody (Center)

Synthetic Peptide

Killer cell immunoglobulin-like receptors (KIRs) are
transmembrane glycoproteins expressed by natural killer cells and
subsets of T cells. The KIR genes are polymorphic and highly
homologous and they are found in a cluster on chromosome 19q13.4
within the 1 Mb leukocyte receptor complex (LRC). The gene content
of the KIR gene cluster varies among haplotypes, although several
'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of
extracellular immunoglobulin domains (2D or 3D) and by whether they
have a long (L) or short (S) cytoplasmic domain. KIR proteins with
the long cytoplasmic domain transduce inhibitory signals upon
ligand binding via an immune tyrosine-based inhibitory motif
(ITIM), while KIR proteins with the short cytoplasmic domain lack
the ITIM motif and instead associate with the TYRO protein tyrosine
kinase binding protein to transduce activating signals. The ligands
for several KIR proteins are subsets of HLA class I molecules;
thus, KIR proteins are thought to play an important role in
regulation of the immune response.

Polyclonal

100132285

Affinity Purified Rabbit Polyclonal Antibody (Pab)

KIR2DS2 Antibody (Center) (Cat. #AP5764c) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the KIR2DS2 antibody detected the KIR2DS2 protein (arrow).

1:1000

IHC-P

KIR2DS2 Antibody (Center) (Cat. #AP5764c) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

1:10~50

Rabbit Ig

39-65

This KIR2DS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of human KIR2DS2.