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MAGEA11 Antibody (N-term)

MAGEA11 Antibody (N-term)

ArtNr	ABC-AP6161a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MAGEA11, MAGE11, Melanoma-associated antigen 11, MAGE-11 antigen, CT111, Cancer/testis antigen 111
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Primary Accession	P43364
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	MAGEA11 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.
Bio References	Rogner, U.C., et al., Genomics 29(3):725-731 (1995). De Plaen, E., et al., Immunogenetics 40(5):360-369 (1994).
Clonality	Polyclonal
Clone/Animal Names	RB2101-2102
Gene ID	4110
Gene Name	MAGEA11 {ECO:0000303\|PubMed:28397838, ECO:0000312\|HGNC:HGNC:6798}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of anti-MAGEA11 Antibody (N-term)(Cat.#AP6161a) pre-incubated with and without blocking peptide in 293 cell line lysate. MAGEA11(arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	NP_005357
Isotype	Rabbit Ig
Calculated MW	48129
Antigen Region	198-228
Antigen Source	HUMAN
Target/Specificity	This MAGEA11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-228 amino acids from the N-terminal region of human MAGEA11.
NCBI Accession	NP_001011544.1; NP_005357.2

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