MLLT1 Antibody (C-term)

Synthetic Peptide

Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t(11; 19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.

Polyclonal

4298

Purified Rabbit Polyclonal Antibody (Pab)

All lanes : Anti-MLLT1 Antibody (D538) at 1:2000 dilution
Lane 1: Raji whole cell lysates
Lane 2: Hela whole cell lysates

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 62 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:2000

WB

Western blot analysis of anti-MLLT1 Pab (Cat. #AP6188a) in A257 cell line lysate (35ug/lane). MLLT1(arrow) was detected using the purified Pab.

1:1000

Rabbit Ig

523-552

This MLLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 523-552 amino acids from the C-terminal region of human MLLT1.