PINK1 (PARK6) Antibody (Center)

Synthetic Peptide

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.

Polyclonal

65018

Purified Rabbit Polyclonal Antibody (Pab)

Park6 (PINK1) Antibody (Center) (Cat. #AP6406b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the Park6 (PINK1) antibody detected the Park6 (PINK1) protein (arrow).

1:1000

Rabbit Ig

237-266

This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human PINK1 (PARK6).