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TIMP1 Antibody (N-term)

TIMP1 Antibody (N-term)

ArtNr	ABC-AP6709a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IF, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TIMP-1, TIMP1, CLGI, TIMP, Metalloproteinase inhibitor 1, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, EPA, Collagenase inhibitor
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Primary Accession	P01033
Antigen Type	Synthetic Peptide
Application	IF, FC, IHC-P, WB
Bio Background	TIMP1 belongs to the TIMP family. The proteins in this family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.
Bio References	Safranek, J., Anticancer Res. 29 (7), 2513-2517 (2009) Onal, I.K., Eur. J. Intern. Med. 20 (4), 369-372 (2009) Okamura, H., Int. J. Oncol. 35 (1), 181-186 (2009)
Clonality	Polyclonal
Clone/Animal Names	RB15494
Gene ID	7076
Gene Name	TIMP1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Confocal immunofluorescent analysis of TIMP1 Antibody (N-term)(Cat#AP6709a) with A2058 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
Type image 1	IF
Dilution image 1	1:10~50
Legend image 2	Western blot analysis of TIMP1 Antibody (N-term) (Cat. #AP6709a) in CEM cell line lysates (35ug/lane). TIMP1 (arrow) was detected using the purified Pab.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Formalin-fixed and paraffin-embedded human breast carcinoma reacted with TIMP1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:10~50
Legend image 4	Flow cytometric analysis of MDA-231 cells using TIMP1 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 4	FC
Dilution image 4	1:10~50
Other Accession	NP_003245
Isotype	Rabbit Ig
Calculated MW	23171
Antigen Region	41-70
Antigen Source	HUMAN
Target/Specificity	This TIMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human TIMP1.
NCBI Accession	NP_003245.1

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Menge: 400 ul

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