PKC beta1/2 Antibody (Center)

Primary Antibodies; Cancer; Cardiovascular; Signal Transduction; Catalog Updated; Anti-Wnt-Pathway (plus Lgr5) Antibodies; Immunity; Fc gamma R-mediated phagocytosis; Inflammation mediated by chemokine and cytokine signaling; Apoptosis signaling

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.

RB1005

Purified Rabbit Polyclonal Antibody (Pab)

76869

303-334

WB: 1:1000
WB: 1:2000
WB: 1:2000
WB: 1:2000
IHC-P: 1:25