PHB2 Antibody (Y128)

ArtNr	ABC-AP7270d
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Prohibitin-2, D-prohibitin, B-cell receptor-associated protein BAP37, Repressor of estrogen receptor activity, PHB2 {ECO:0000312\|EMBL:AAH147661, ECO:0000312\|HGNC:HGNC:30306}
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Primary Accession	Q99623
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.
Bio References	Takata, H., Curr. Biol. 17 (15), 1356-1361 (2007) Kasashima, K., J. Biol. Chem. 281 (47), 36401-36410 (2006)
Clonality	Polyclonal
Clone/Animal Names	RB15314
Gene ID	11331
Gene Name	PHB2 {ECO:0000312\|EMBL:AAH14766.1, ECO:0000312\|HGNC:HGNC:30306}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Western blot analysis of PHB2-Y128(Cat. #AP7270d) in mouse NIH-3T3 cell line lysates (35ug/lane).PHB2 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	All lanes : Anti-Phospho-PHB2-Y128. ctrl at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: 293 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 33 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PHB2 Antibody (Y128) (Cat.#AP7270d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 3	IHC-P
Dilution image 3	1:10~50
Other Accession	Q5XIH7; O35129; Q5ZMN3; Q2HJ97; NP_009204
Predicted	B, C, Rat
Isotype	Rabbit Ig
Calculated MW	33296
Antigen Region	106-134
Antigen Source	HUMAN
Target/Specificity	This PHB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from human PHB2.
NCBI Accession	NP_001138303.1; NP_001254629.1

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