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AMPK2 Antibody (Center)

AMPK2 Antibody (Center)

ArtNr	ABC-AP7411c-ev-80ul
Hersteller	Abcepta
Menge	80 ul
Kategorie	Oncology Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Hematology Lymphoma Cell Biology Obesity Cell Status Western Blot Autophagy Enzymes Fatty Acid Synthesis Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	Western Blot
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, PRKAA2, AMPK, AMPK2
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Primary Accession	P54646
Other Accession	Q09137; Q28948; Q8BRK8
Antigen Type	Synthetic Peptide
Bio Background	AMPK2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Bio References	Wyatt, C.N., J. Biol. Chem. 282 (11), 8092-8098 (2007) Cheung, S.T., Neoplasia 8 (9), 696-701 (2006) Lee-Young, R.S., Am. J. Physiol. Endocrinol. Metab. 291 (3), E566-E573 (2006) Gregory, S.G., Nature 441 (7091), 315-321 (2006)
Gene ID	5563
Gene Name	PRKAA2
Reactivity	H
Predicted	M, Pig, Rat
Calculated MW	62320
Antigen Region	265-294
Antigen Source	HUMAN
Target/Specificity	This AMPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the Central region of human AMPK2.
NCBI Accession	NP_006243.2

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