APOE Antibody (C-term)

Synthetic Peptide

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Polyclonal

348

Purified Rabbit Polyclonal Antibody (Pab)

All lanes : Anti-APOE Antibody (C-term) at 1:1000 dilution
Lane 1: Human plasma lysate
Lane 2: Mouse plasma lysate
Lane 3: Human ovary lysate
Lane 4: Mouse liver lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 36 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:1000

IHC-P

P18287; P10517

Rabbit Ig

263-292

This APOE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human APOE.