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PCSK2 Antibody (N-term)

PCSK2 Antibody (N-term)

ArtNr	ABC-AP7617A
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IF, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PCSK2, PC2, NEC2, KEX2-like endoprotease 2, NEC 2, Neuroendocrine convertase 2, Prohormone convertase 2, Proprotein convertase 2
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Primary Accession	P16519
Antigen Type	Synthetic Peptide
Application	FC, IF, IHC-P, WB
Bio Background	PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.
Bio References	Leak, T.S., Keene, K.L. Mol. Genet. Metab. 92 (1-2), 145-150 (2007) Shen, X., Li, Q.L. Am. J. Physiol. Endocrinol. Metab. 288 (1), E236-E245 (2005) Tzimas, G.N., Chevet, E. BMC Cancer 5, 149 (2005) Seidah, N.G., Mattei, M.G. Genomics 11 (1), 103-107 (1991)
Clonality	Polyclonal
Clone/Animal Names	RB18543
Gene ID	5126
Gene Name	PCSK2
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Confocal immunofluorescent analysis of PCSK2 Antibody (N-term)(Cat#AP7617a) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Type image 1	IF
Dilution image 1	1:10~50
Legend image 2	Anti-PCSK2 Antibody (N-term) at 1:1000 dilution + TT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 71 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Western blot analysis of PCSK2 Antibody (N-term) (Cat. #AP7617a) in mouse cerebellum tissue lysates (35ug/lane). PCSK2 (arrow) was detected using the purified Pab.
Type image 3	WB
Dilution image 3	1:1000
Legend image 4	Formalin-fixed and paraffin-embedded human brain tissue reacted with PCSK2 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 4	IHC-P
Dilution image 4	1:10~50
Legend image 5	PCSK2 Antibody (N-term) (Cat. #AP7617a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 5	FC
Dilution image 5	1:10~50
Other Accession	P28841; Q03333; P21661
Predicted	Pig, Rat
Isotype	Rabbit Ig
Calculated MW	70565
Antigen Region	87-116
Antigen Source	HUMAN
Target/Specificity	This PCSK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human PCSK2.
NCBI Accession	NP_001188457.1; NP_001188458.1; NP_002585.2

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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ABC-AP7617A-datasheet.pdf

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Menge: 400 ul

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